Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose combination

Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose combination

Type 2 diabetes has become a major burden to the health care systems worldwide. Among the drugs approved for this indication, glimepiride and rosiglitazone have gained substantial importance in routine use. While glimepiride stimulates beta-cell secretion and leads to reduction of blood glucose values, rosiglitazone activates PPARgamma and improves insulin resistance, at the vascular and metabo...

Effect of fixed-dose combination (FDC) drugs on development of clinical antimicrobial resistance: a review paper

The emergence of previously unreported infectious diseases, the re‐emergence of infectious disease thought to have been on the way to elimination, and the rapid evolution of infectious pathogens exhibiting antimicrobial resistance (“AMR”) and in particular, multiple‐drug resistance (“MDR”) have created a major clinical and public health threat of global dimensions. The idea that AMR can be del...

Fixed-dose combination rosiglitazone/glimepiride in the treatment of Type 2 diabetes mellitus

Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review

The family practitioner plays an important role in the prevention, diagnosis, and early management of chronic pain. He/she is generally the first to be consulted, the one most familiar with the patients and their medical history, and is likely the first to be alerted in case of inadequate pain control or safety and tolerability issues. The family practitioner should therefore be at the center o...

Fixed-dose combination Therapy in Hypertension: Focus on Fixed-dose combination of Amlodipine and Valsartan (exforge®)

Hypertension is the leading cause of disability and cardiovascular mortality world-wide. Approximately one-third of the US adult population and over a billion people world-wide have hypertension. Despite increased awareness of hypertension and availability of many effective antihypertensive agents, only one third of patients achieve their target blood pressure (BP). All expert panels now recomm...